Osteoarthritic subchondral bone marrow histology. Lessons from changes in alkaptonuria

Meniscal extrusion predicts increases in subchondral bone marrow lesions and bone cysts and expansion of subchondral bone in osteoarthritic knees.

OBJECTIVES Meniscal extrusion is often present in knees with OA, and has been associated with cartilage changes. It is unknown whether meniscal extrusion is related to subchondral bone. The aim of the study was to examine the relationship between meniscal extrusion and knee cartilage and subchondral bone, and also changes in these structures over 2 years in a cohort with mild to moderate knee O...

Subchondral bone histology and grading in osteoarthritis

OBJECTIVE Osteoarthritis (OA) has often regarded as a disease of articular cartilage only. New evidence has shifted the paradigm towards a system biology approach, where also the surrounding tissue, especially bone is studied more vigorously. However, the histological features of subchondral bone are only poorly characterized in current histological grading scales of OA. The aim of this study i...

Interactions between subchondral bone and cartilage in OA. Cells from osteoarthritic bone can alter cartilage metabolism.

Subchondral Bone Sclerosis Increases In Both Trabecular Bone And Subchondral Plate In Human Knee Osteoarthritis : Relationship With Histology

Introduction: Osteoarthritis (OA) is a disease of a whole joint. Yet most of the diagnostic methods are focused mainly on cartilage degeneration and erosion. However, there is increasing evidence that the subchondral bone significantly contributes to the pathogenesis of OA. It has even been suggested that first tissue-level changes in OA occur in the subchondral bone before any signs of degener...

Strontium ranelate inhibits key factors affecting bone remodeling in human osteoarthritic subchondral bone osteoblasts.

INTRODUCTION In osteoarthritis (OA) the progression of cartilage degeneration has been associated with remodeling of the subchondral bone. Human OA subchondral bone osteoblasts were shown to have an abnormal phenotype and altered metabolism leading to an abnormal resorptive process. Bone resorption is suggested to occur, at least in part, through the increased levels of two proteolytic enzymes,...